In my experience, whatever the macro does, if it is intended to give always 
the same output, it is always more efficient to keep either macro or its 
output out of the while loop, but inside a union for instance. Otherwise it 
would not make too much difference (except maybe if the macro is very 
large); e.g.

#declare my_output = macro();
union {
#while (counter <= 200)
business as usial
#declare counter = counter+1;
#end
my_output //whatever that represents
}//end of union


Thomas

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