I suggest the following:
- Upgrade your BIOS if you haven't already, most MoBo(MotherBoard)
manufacturers recommend you to do so when you upgrade from 1 to 2 or
from 2 to 4. This is not very important, but is recommendable to avoid
incompatibility issues and maybe to add small/big improvements to your
MoBo functionality.

- Check in the BIOS Setup a option for "USB Mouse Support" if it has one.

- Download new drivers or use the current ones, just don't configure all
the buttons or set them to do nothing and configure the 3 buttons you
use to work as you have now, but probably you wont have to do anything
as those 3 buttons defaults are good enough, except maybe the
middle/third one. I don't think it would be too hard to do.

- You said you put some new software, what software? new version
Windows? if so that maybe is the reason.

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