> My site is about high resolution 3D graphics and multimedia applications 
> mainly. It makes no sense to target hand-held devices, or blind people for 
> that matter in this case. Rather, on their high resolution monitors, which 
> I *know* my intended audience have, I want the site to look good.

And even if you do have a site that could be used by mobile devices, you 
usually make a site dedicated for that device.  I use mobile.msn.com (or 
whatever it is) all the time on my phone to check my hotmail - it would be 
totally absurd if it had all the same content as the main hotmail site, no 
matter what layout was used.

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